A clear operating model for a multi-decade program.
The initiative's governance framework is deliberately structured to preserve scientific rigor, protect patient interests, and enable sustained growth — while dividing responsibility cleanly across three institutions.
HIER Institute
Advanced imaging analytics, artificial intelligence, registry development, translational science, regulatory operations, and industry partnerships.
Heart Spark RII
Scientific collaboration, education, trainee development, patient engagement, dissemination, and philanthropic support.
Dartmouth Radiation Oncology
Treatment-planning CT, dosimetry, radiation delivery, longitudinal outcomes, and multidisciplinary faculty across cardio-oncology, radiology, medical physics, and AI.
One master. Many sub-studies.
The scientific program is structured as an umbrella master protocol under which retrospective, prospective, AI, radiomics, imaging biomarker, implementation science, and outcomes investigations can proceed through amendments rather than new IRB submissions.
Existing planning CT, dose maps, EHR, laboratory, cardiovascular imaging, medications, and longitudinal outcomes — under HIPAA waiver of consent.
Prospective enrollment, informed consent, biospecimen collection, patient-reported outcomes, wearables, and long-term follow-up.
Development, validation, and deployment of deep learning models on de-identified imaging and structured data.
Feature extraction pipelines, harmonization, and predictive signature discovery.
Standard operating procedures for image acquisition, dose extraction, segmentation, quality control, and annotation.
Data flow, security, REDCap dictionaries, case report forms, and audit procedures.